Harriet de Wit, Ph.D

Education & Training

• PhD (Experimental Psychology), Concordia University Montreal, 1981
• Registered Psychologist, State of Illinois (No. 072-003576)

Research Interests

• Human psychopharmacolgy of substance abuse
• Stress, impulsivity and cue reactivity
• Genetics and individual differences in responses to drugs of abuse

Teaching

• Course Director, Perspectives in Drug Abuse, Spring quarter, Pha 329, 1992-
• Research mentor, Illinois Mathematics and Science Academy, 1998-
• Mentor, Summer Research Program, Pritzker School of Medicine, 2004-
• http://pritzker.uchicago.edu/current/students/summerresearch_cal.shtml
• Mentor, graduate students and post doctoral fellows
• Training faculty, NIDA pre- and post-doctoral training grant, 1990-
• http://nida-training-program.bsd.uchicago.edu/
• Training faculty, Clinical Pharmacology Fellowship program, 1993-

Society Memberships

• American College of Neuropsychopharmacology: Member 1996-; Fellow 2003-
• American Psychological Association (Division 28): Fellow 1995-
• Brain Research Institute, The University of Chicago, 1996-
• Society for Neuroscience, 2002-
• College on Problems of Drug Dependence: Fellow 2000-; Board of Directors 1997-2000
• Research Society on Alcoholism: Board of Directors 1999-2003
• Society for Research on Nicotine and Tobacco: Member 2004-
• International Society of Addiction Journal Editors: Member 2006-

Selected Publications (2006 – 2008)

• Childs, E., H. de Wit. Physiological, hormonal and subjective responses to acute stress in smokers. Psychopharmacology DOI 10.1007/s00213-008-1359-5
• de Wit, H. Impulsivity as a determinant and consequence of drug use: A review of underlying processes. Addiction Biology. doi:10.1111/j.1369-1600.2008.00129
• Phan, K.L., M. Angstadt, J. Golden, I. Onyewuenyi, A. Popovska, H. de Wit (2008) Cannabinoid modulation of amygdala reactivity to social signals of threat in humans. The Journal of Neuroscience, 28, 2313–2319.
• Acheson, A., H. de Wit (2008) Bupropion improves attention but does not affect impulsive behavior in healthy men and women. Experimental and Clinical Psychopharmacology. 16, 113-123
• Miczek, K.A., H. de Wit (2008) Challenges for translational psychopharmacology research - Some basic principles. Psychopharmacology. 199, 291-301
• Childs E, de Wit H. (2008) Enhanced mood and psychomotor performance by a caffeine-containing energy capsule in fatigued individuals. Exp Clin Psychopharmacol. 16, 13-21.
• Hamidovic, A., Kang, U., de Wit, H. (2008) Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers. Journal of Clinical Psychopharmacology, 28, 45-51.
• Childs A., C. Hohoff, C., J. Deckert, X. Ke, J. Badner, H. de Wit (2008) Association between A1, A2a and DRD2 receptor gene polymorphisms and behavioural effects of caffeine. Neuropsychopharmacology. PMID: 18305461
• Dlugos, A., C. Freitag, C. Hohoff, J. McDonald, E.H. Cook, J. Deckert, H. de Wit (2007) Norepinephrine transporter gene variation modulates acute response to d-amphetamine. Biological Psychiatry 61, 1296-1305
• Acheson, A., Richards, J.B., de Wit H. (2007) Effects of sleep deprivation on performance. Physiology and Behavior, 91, 579-587
• White, T.L., C. W. Lejuez and H. de Wit (2007) Personality and gender differences in effects of d-amphetamine on risk-taking. Journal of Clinical and Experimental Psychopharmacology. 15, 599-609.
• Childs, E., & de Wit, H. (2006) Subjective, behavioural and physiological effects of acute caffeine administration in light, non-dependent caffeine users. Psychopharmacology, 185(4):514-23.
• Hariri, A.R., Brown, S.M., Williamson, D.E., Flory, J.D., de Wit, H., S.B. Manuck (2006) Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. J. Neurosci. 26, 13213-7
• de Wit, H., J.D. Flory, A. Acheson, M. McCloskey, S.B. Manuck. (2007) IQ and Nonplanning Impulsivity are independently associated with delay discounting in middle-aged adults. Personality and Individual Differences 42, 111-121
• Childs, E., Vicini, L., & de Wit, H. (2006) Responses to the Trier Social Stress Test (TSST) in single versus grouped participants. Psychophysiology, 43(4):366-71.
• de Wit, H., Vicini, L., Childs, E., Sayla, M., Terner, J. (2006) Does stress reactivity or response to d-amphetamine predict progression to smoking in young adults? A preliminary study. Pharmacol Biochem Behav. 2007 Feb;86(2):312-9
• White, T.L., Grover, V.K., de Wit, H. (2006) Cortisol effects of d-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Pharmacology, Biochemistry and Behavior, 85, 123-131.
• Lott, D. C., Kim, S. J., Cook, E. H., & de Wit, H. (2006) Serotonin transporter genotype and acute subjective response to amphetamine. American Journal on Addictions, 15(5):327-35.
• King, A., de Wit, H., Riley, R. C., Cao, D., Niaura, R., & Hatsukami, D. (2006) Efficacy of naltrexone in smoking cessation: A preliminary study and an examination of sex differences. Nicotine and Tobacco Research. 8(5):671-82.

• Acheson, A., Reynolds, B., Richards, J. B., & de Wit, H. (2006) Diazepam impairs behavioral inhibition but not delay discounting or risk taking in healthy adults. Experimental and Clinical Psychopharmacology, 14(2):190-8.

• de Wit, H., Vicini, L., Haig, G., Hunt, T., & Feltner, D. (2006) Evaluation of the abuse potential of pagoclone, a partial GABA a agonist. Journal of Clinical Psychopharmacology, 26(3):268-73
• Acheson A., Farrar A.M., Patak M., Hausknecht, K.A., Kieres, A.K., Choi, S. de Wit H., Richards, J.B. (2006) Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behav Brain Research, 173, 217-228.
• Flanagin, B. A., de Wit, H., & Cook, Jr, E. H. (2006) Association study of the brain-derived neurotrophic factor Val66Met polymorphism and amphetamine response. Neuropsychiatric Genetics, 141B, 576-583.
• Terner, J. M., & de Wit, H. (2006). Menstrual cycle phase and responses to drugs of abuse. Drug and Alcohol Dependence, 84, 1-13.
• Reynolds, B., Ortengren, A., Richards, J. B., & de Wit, H. (2006). Dimensions of impulsive behavior: Personality and behavioral measures. Personality and Individual Differences, 40, 305-315.
• Acheson, A., Mahler, S. V., Chi, H., & de Wit, H. (2006) Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology. 186(1):54-63.
• King, A., Munisamy, G., de Wit, H. & Lin, S. (2006) Attenuated cortisol response to alcohol in heavy social drinkers. International Journal of Psychophysiology, 59, 203-209.
• Reynolds, B., Richards, J. B., & de Wit, H. (2006) Acute alcohol effects on laboratory measures of impulsive behavior in humans. Pharmacology, Biochemistry and Behavior, 83(2):194-202
• de Wit, H. and L. Phan (in press) Positive reinforcement theories of drug use. In: Substance Abuse and Emotion, Ed. Jon D. Kassel, American Psychological Association, Washington DC.
• de Wit, H. and S. Mitchell (in press) Drug Effects on Delay Discounting. In: Impulsivity: Theory, Science, and Neuroscience of Discounting Eds: G. J. Madden, W. K. Bickel, & T. S. Critchfield American Psychological Association, Washington DC

Other Activities (non- University of Chicago)

• Field Editor, Psychopharmacology, Alcohol and Substance Abuse in Humans; Human Cognitive Psychopharmacology, 1993 –
• http://www.springer.com/biomed/neuroscience/journal/213
• Deputy Editor, Alcoholism: Clinical and Experimental Research, 2003 –
• http://www3.interscience.wiley.com/journal/118520059/home
• Scientific Advisory Board, Alcohol Research Center, Medical University of South Carolina, 2000 -
• Scientific Advisory Board, Alcohol Research Center, University of Connecticut, 1999 -
• Scientific Advisory Board, Center for Drug Abuse Research Translation, University of Kentucky, 2004 –
• Scientific Advisory Board, Alcohol Research Center, Oregon Health Sciences University, Portland Oregon, 2007 –
• Consultant, Center for Drug Evaluation, Food and Drug Administration, 1991 -
• Advisory Board, Sci-Mat Betty Ford Center News, 2006 –
• Advisory Board, Current Drug Abuse Reviews, 2006 –
• Member, Faculty of 1000, 2004-
• Editorial Advisory Board The Open Addiction Journal, 2008 -
• Education and Training Committee, American College of Neuropsychopharmacology, 2006-2010
• Member, International Society Addiction Journal Editors, 2006 – [http://www.parint.org/isajewebsite/index.htm]
• Editorial Board, Encyclopedia of Psychopharmacology, Ed. Ian Stolerman, 2007 -

Other Activities (University of Chicago)

• Scientific Advisory Committee, Clinical Research Center, 1989 -
• Executive Committee, Clinical Pharmacology Fellowship Program, 1993 -
• Executive Committee, NIDA Training Grant “Neuropsychopharmacology of Drug Abuse” 1990 -
• University of Chicago Cancer Research Center, 2004 -
• Mentor, Illinois Mathematics and Science Academy, 1996 -
• Member, Center for Cognitive and Social Neuroscience, 2005 -
• Member, Committee on Appointments and Promotions, Biological Sciences Division, 2006 -
• Member, Faculty Advisory Committee of the Biostatistics Core Facility, 2007 –
• Pritzker School of Medicine Summer Res Prog: Mentor, Cluster leader, Judge, 2004 –
• Elected member of the Council of the University Senate, 2008 -