| Department of Psychiatry |
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| Specialty: Neurobiology of learning and memory, mouse genetics, neurobiology of mental disease | |||||||||||||
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1982, Bachelor’s degree in Medicine, Luchow Medical College, China, majoring in Medicine 1989, Master’s degree in Science, Shanghai Second Medical University, China majoring in Neurobiology 1998, Ph.D., Nagoya University, Japan, majoring in Molecular Biology and Neurobiology 2001, Post-doctor, Princeton University, majoring in Neurobiology and Mouse Genetics 2001, to now, Assistant Professor, Department of Psychiatry, The University of Chicago, majoring in Neurobiology |
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| Selected Publications: Tang, Y-P, Shimizu, E, Dube, G, Rampon, C, Keercher, G, Zhou, M, Liu, G and Tsien, JZ (1999) Genetic enhancement of learning and memory in mice. Nature 401: 63-69.
Tang, Y-P*, Rampon, C*, Goodhouse,
J, Shimizu, E, Kyin, M and Tsien,
JZ (2000) Enrichment induces structural changes and recovery from
nonspatial
memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci
3: 238-244.
Rampon,
C, Jiang, CH, Dong, H, Tang, Y-P,
Lockhart, DJ, Schultz, PG, Tsien, JZ and Hu, Y (2000) Effects of
environmental
enrichment on gene expression in the brain. Proc Natl Acad
Sci USA 97: 12880-12884.
Tang, Y-P*, Shimizu, E*, Rampon, C
and Tsien, JZ (2000) NMDA
receptor-dependent synaptic reinforcement as a crucial process for
memory
consolidation. Science
290:1170-1174.
Feng,
R, Rampon, C, Tang, Y-P, Shrom, D,
Jin, J, Kyin, M, Sopher, B, Miller, MW, Ware, CB, Martin, GM, Kim, SH,
Langdon,
RB, Sisodia, SS, Tsien, JZ (2001) Deficient neurogenesis in
presenilin-1
forebrain knockout mice prevents clearance of hippocampal memory
traces. Neuron 32: 911-926.
Wang,
H, Shimizu, E, Tang, Y-P, Cho, M,
Kyin M, Zuo W, Robinson, DA, Alaimo, AP, Zhang Cc, Morimoto, H, Zhuo,M,
Feng,
R, Shokat, KM, Tsien, JZ (2003) In vivo conditional
protein knockout for temporal analysis of memory
consolidation
in mice. Proc Natl Acad Sci USA
100: 428742-92. Lazaroy, O, Robinson, J, Tang, Y-P, Hairston, IS, Korade-Mirnics, Z., Lee, V,
Hersh, LB, Sapolsky, RM, Mirnics, K, and Sisodia, SS (2005)
Environmental enrichment reduces a-b
levels and amyloid deposition in transgenic mice. Cell.
120: 701-713.
Chen, Q, Nakajima, A,
Meacham, C, Tang, Y-P (2006) Elevated CCKergic tone
constitutes an important
molecular/neuronal mechanism for the expression of anxiety in the
mouse. Proc Natl Acad Sci USA 103: 3881-3886.
Kim SH, Tang,
Y-P,
Sisodia SS (2006) A-beta star: a light onto synaptic dysfunction? Nat
Med 12: 760-761. *: these authors contributed equally to the work. |
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