About:

Dr. Goldman received his MD from the University of Pennsylvania and completed his residency in psychiatry and a fellowship in psychoneuroendocrinology at the University of Chicago. His clinical interests are in chronic severe mental illness, particularly schizophrenia. His research interests are in disorders of water balance in schizophrenia and their relationship to the underlying mental illness.  This is currently focused on the role of the hippocampal formation in schizophrenia, the treatment effects of oxytocin in patients with water imbalance, and the neurocircuitry of prepulse inhibition in schizohprenia.  For more information about the Schizophrenia Research Program click here, and for clinical services here.

• Goldman MB, Luchins DJ:  Prevention of episodic water intoxication with  target weight procedure.  American Journal of Psychiatry, 144:365-366, 1987.

• Goldman MB, Luchins DJ, Robertson GL:  Mechanisms of altered water metabolism in psychotic patients with polydipsia and hyponatremia.  New  England Journal of Medicine, 318:397-403, 1988.

• Goldman MB, Luchins DJ, Robertson GL:  Treatment of hyponatremia secondary to water overload.  Lancet, i:328-329, 1989.

• Goldman MB, Blake L, Marks RC:  Association of nonsuppression of cortisol on the DST with primary polydipsia in chronic schizophrenia.  American Journal of Psychiatry, 150:653-655, 1993.

• Goldman MB, Luchins DJ, Robertson GL, Hedeker D, Pandey GH:  Psychotic exacerbations and enhanced vasopressin in schizophrenics with hyponatremia and polydipsia.  Archives of General Psychiatry, 54: 443-449, 1997.
  

• Goldman MB, Mitchell CP: What is the Functional Significance of the Hippocampal Pathology in Schizophrenia? Schizophrenia Bulletin 30:367-392, 2004.

•   Mitchell CP, Goldman MB. Neonatal lesions of the ventral hippocampal formation disrupt neuroendocrine  responses to auditory stress in the adult rat. Psychoneuroendocrinology 29: 1317-1325, 2004.

• Mitchell CP, Grayson DR, Goldman MB. Neonatal Lesions of the Ventral Hippocampal Formation Alter GABA-A Receptor Subunit mRNA Expression in Adult Rat Frontal Pole.  Biological Psychiatry  57:49-55,2005.

• Goldman, MB, Heidinger L, Kulkarni K, Zhu DC, Chien A, McLaren DG,  Shah J, Coffey Jr. CE, Sharif S, Chen E, Uftring SJ, Small SL, Solodkin A, Pilla R.  Changes in the Amplitude and Timing of the Hemodynamic Response Associated with Prepulse Inhibition of Acoustic Startle.  Neuroimage  32:1375-1384, 2006.

• Goldman, MD, Hussain H, Wood G, Goldman MB, Gavin M, Paul S, Zaheer S, Fayyaz,G, R. Pilla.: Mechanism of impaired corticosteroid negative feedback in schizophrenia.  Journal of Clinical Endocrinology and Metabolism, 32:698-704, 2007.

• Goldman MB, Hussain N, Gnerlich J.: Enhanced neuroendocrine responses to psychological stress in schizophrenic patients with polydipsia and hyponatremia. Neuropsychopharmacology 32:1611-1621, 2007.

• Goldman MB, Torres IJ, Keedy S, Marlow-O’Connor M, Beenken B.: Reduced anterior hippocampal formation volume in hyponatremic schizophrenic patients.: Hippocampus, 17:554-562, 2007.

• Goldman MB, Marlow-O’Connor M, Torres I,  Carter CS. Preliminary data on diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits (in press Schizophrenia Research).