Center for Psychiatric Genetics (CPG), North Shore University Hospital

The CPG is home of a psychiatric genetics research program with emphasis on schizophrenia. The field has shown remarkable progress during the last years, which well replicated findings of common and rare genetic variation associated with schizophrenia. The main thrust of CPG has been the design and implementation of large-scale, multi-site international studies, from systematic linkage scans to genome-wide association studies (GWAS) (see list of selected publications), and the follow-up of functional studies to unravel the physiological mechanisms underlying genetic associations. Financial support derives from a variety of public and private sources, including NUH, The Brain and Behavior Research Foundation (formerly NARSAD, the National Alliance for Research on Schizophrenia and Depression), The Paul Michael Donovan Charitable Foundation, and Federal (NIH –National Institutes of Health) Research Grants.

Investigators:

Pablo V. Gejman, 224-364-7550
Professor (Part-Time)                                                       pgejman@uchicago.edu

Dr. Louis W. Sauer
Chair of Research Director,
Center for Psychiatric Genetics NUH
Professor, Department of Psychiatry
The University of Chicago                                                                        

Alan R. Sanders, 224-364-7560
Director, Behavior Genetics Unit
Center for Psychiatric Genetics NUH
Clinical Associate Professor of Psychiatry
arsander@uchicago.edu

Jubao Duan, 224-364-7564                                                                 Assistant Professor (Part-Time)    
Center for Psychiatric Genetics NUH                                              Department of Psychiatry                                                                        The University of Chicago  
jduan@uchicago.edu

Winton Moy, 224-364-7567
Postdoctoral Fellow
Center Psychiatric Genetics NUH
wmoy@northshore.org

   

Publications:

 

  1. Transcriptome study of differential expression in schizophrenia. Sanders AR, Göring HH (co-first author), Duan J, Drigalenko EI, Moy W, Freda J, He D, Shi J; MGS, Gejman PV. Hum Mol Genet. 2013
  2. Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell lines. Duan J, Shi J, Ge X, Dolken L, Moy W, He D, Shi S, Sanders AR, Ross J, Gejman PV. Sci Rep. 2013
  3. Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. Fanous AH, Zhou B, Aggen SH, Bergen SE, Amdur RL, Duan J, Sanders AR, Shi J, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Freedman R, Dudbridge F, Holmans PA, Ripke S, Gejman PV, Kendler KS, Levinson DF; Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Am J Psychiatry. 2012
  4. Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, Lin DY, Duan J… 185  other authors …, O'Donovan MC, Daly MJ, Gejman PV. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011
  5. Genetics of Schizophrenia: New Findings and Challenges. Gejman PV, Sanders AR, Kendler KS. Annu Rev Genomics Hum Genet. 2011.
  6. Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Levinson DF, Duan J, Oh S, Wang K, Sanders AR, Shi J, Zhang N, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Kendler KS, Freedman R, Dudbridge F, Pe'er I, Hakonarson H, Bergen SE, Fanous AH, Holmans, PA, Gejman PV. Am J Psychiatry. 2011.
  7. The Internet-based MGS2 control sample: self report of mental illness. Sanders AR, Levinson DF, Duan J, Dennis JM, Li R, Kendler KS, Rice JP, Shi J, Mowry BJ, Amin F, Silverman JM, Buccola NG, Byerley WF, Black DW, Freedman R, Cloninger CR, Gejman PV. Am J Psychiatry. 2010.
  8. The role of genetics in the etiology of schizophrenia. Gejman PV, Sanders AR, Duan J. Psychiatr Clin North Am. 2010.
  9. Common variants on chromosome 6p22.1 are associated with schizophrenia. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, Dudbridge F, Holmans PA, Whittemore AS, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Crowe RR, Oksenberg JR, Mirel DB, Kendler KS, Freedman R, Gejman PV. Nature. 2009.
  10. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M, Gejman PV. Am J Psychiatry. 2008.
  11. New models of collaboration in genome-wide association studies: the Genetic Association Information Network. GAIN Collaborative Research Group, Manolio TA, Rodriguez LL, Brooks L, Abecasis G; Collaborative Association Study of Psoriasis, Ballinger D, Daly M, Donnelly P, Faraone SV; International Multi-Center ADHD Genetics Project, Frazer K, Gabriel S, Gejman PV; Molecular Genetics of Schizophrenia Collaboration, Guttmacher A, Harris EL, Insel T, Kelsoe JR; Bipolar Genome Study, Lander E, McCowin N, et al. Nat Genet. 2007.
  12. Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C, Buccola NG, Hale N, Weilbaecher AN, Nertney DA, Olincy A, Green S, Schaffer AW, Smith CJ, Hannah DE, Rice JP, Cox NJ, Martinez M, Mowry BJ, Amin F, Silverman JM, Black DW, Byerley WF, Crowe RR, Freedman R, Cloninger CR, Levinson DF, Gejman PV. Am J Hum Genet. 2006.
  13. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV. Hum Mol Genet. 2003.