Chunyu Liu, Ph.D.
Assistant Professor
| Address: | 924 E. 57th Street, R012 Chicago, Illinois 60637 |
| Phone: | 773-834-3604 |
| Fax: | 773-834-2970 |
| Email: | cliu@yoda.bsd.uchicago.edu |
Education & Training
- B.S. Biochemistry, Biology Department, Wuhan University, PR. China, 1991
- M.S. Cell Biology, Biology Department, Xiamen University, PR China, 1994
- Ph.D. Genetics, National Lab of Medical Genetics of China, Hunan Medical University, PR.China, 1998
Research Interests
- Chunyu Liu’s major research interests are in the areas of genetics, genomics, and epigenomics of neuropsychiatric diseases, particularly Bipolar Disorder and Schizophrenia.
- Four major ongoing projects are:
- microRNA in bipolar disorder and schizophrenia: looking for variants in miRNAs that might be related to the diseases;
- gene expression regulation in human brain: map gene expression controllers in brain;
- CNVs and SNPs in whole genome association study of bipolar disorder: looking for SNP/CNV association with the disease;
- G72 transgenic mice: study biochemical, genomic, and behavioral changes in a human BAC transgenic mice that may serve as a model for human psychiatric diseases.
Teaching
- Programming for Modern Biomedical Research. BIOS 20250. Biological Sciences Collegiate Division.
Selected Publications
- Dandan Zhang, Lijun Cheng, Yudong Qian, Ney Alliey-Rodriguez, John R. Kelsoe, Tiffany Greenwood, Caroline Nievergelt, Thomas B. Barrett, Rebecca McKinney, Nicholas Schork, Erin N. Smith, Cinnamon Bloss, John Nurnberger, Howard J. Edenberg, Tatiana Foroud, William Sheftner, William B. Lawson, Evaritus A. Nwulia, Maria Hipolito, William Coryell, John Rice, William Byerley, Francis McMahon, Thomas G. Schulze, Wade Berrettini, James B. Potash, Pamela L. Belmonte, Peter P. Zandi, Melvin McInnis, Sebastian Zöllner, David Craig, Szabolics Szelinger, Daniel Koller, Susan L. Christian, Chunyu Liu*, Elliot S. Gershon* Singleton deletions throughout the genome increase risk of bipolar disorder. Molecular Psychiatry. 2008 Dec 30 (*co- corresponding author).
- Manjula Maheshwari, Jiajun Shi, Judith A. Badner, Andrew Skol, Virginia L.Willour, Donna M Muzny, David A Wheeler, Fowler R Gerald, Sevilla Detera-Wadleigh, Francis J. McMahon, James B. Potash, Elliot S. Gershon, Chunyu Liu*, Richard A. Gibbs. Common and rare variants of G72 in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2009, Feb 4 (*corresponding author).
- Jiajun Shi, Judith A. Badner, Virginia L. Willour, James B. Potash, Elliot S. Gershon, Chunyu Liu. Further evidence for an association of G72/G30 with schizophrenia in Chinese. Schizophrenia Research. 2009 Feb;107(2-3):324-6.
- Jiajun Shi, Elliot S. Gershon, and Chunyu Liu. Genetic associations with schizophrenia: meta-analyses of 12 “top” genes. Schizophrenia Research. 2008. 104(1-3):96-107.
- Jiajun Shi, Judith A. Badner, Eiji Hattori, James B. Potash, Virginia L. Willour, Francis J. McMahon, Elliot S. Gershon, and Chunyu Liu. Neurotransmission and bipolar disorder: a systematic family-based association study. Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1270-7.
- Jiajun Shi, Jacqueline K. Wittke-Thompson, Judith A. Badner, Eiji Hattori, James B. Potash, Virginia L. Willour, Francis J. McMahon, Elliot S. Gershon, and Chunyu Liu. Clock Genes may Influence Bipolar Disorder Susceptibility and Dysfunctional Circadian Rhythm. Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1047-55.
- Jiajun Shi, Judith A. Badner, Elliot S. Gershon, and Chunyu Liu. Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis. Schizophrenia Research. 2008. 98(1-3):89-97.
- Jiajun Shi, Judith A. Badner and Chunyu Liu. PDLIM5 and susceptibility to bipolar disorder: a family-based association study and meta-analysis. Psychiatric Genetics. 2008. 18(3):116-121.
- Chunyu Liu, Jiajun Shi, Judith A. Badner, Hongwei Zou, Yudong Qian, Elliot S. Gershon. No Association of Trace Amine Receptor Genes with Bipolar Disorder. Molecular Psychiatry. 2007. 12(11):979-981.
- Jiajun Shi, Eiji Hattori, Hongwei Zou, Judith A Badner, Susan L Christian, Elliot S Gershon, Chunyu Liu. Association Analysis of 19 Cholinergic Genes with Bipolar Disorder. Am J Med Genet B Neuropsychiatr Genet. 2007. 144(6):715-23.
- Fengxia Yao, Ruifang Zhang, Zanhua Zhu, Kun Xia, Chunyu Liu. MutScreener: primer design tool for PCR- direct sequencing. MutScreener: primer design tool for PCR- direct sequencing. Nucleic Acids Res. 2006. 34(Web Server issue):W660-4.
- Chunyu Liu, Tom I. Bonner, Tu Nguyen, Jennifer L. Lyons, Susan L. Christian, Elliot S. Gershon. DNannotator: annotation software tool kit for regional genomic sequences. Nucleic Acids Res. 2003. 31(13):3729-3735.
- Eiji Hattori*, Chunyu Liu*, Judith A. Badner, Tom I. Bonner, Susan L. Christian, Manjula Maheshwari, Sevilla D. Detera-Wadleigh, Richard A. Gibbs, Elliot S. Gershon. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. American Journal of Human Genetics. 2003. 72:1131-1140 (*equal contribution).
Other Activities
- Committee on Molecular Medicine
- Committee on Genetics
- Fellow of Institute for Genomics & Systems Biology
- College Council, The University of Chicago
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