Center for Psychiatric Genetics (CPG), NorthShore University HealthSystem

The CPG is the home of a psychiatric genetics research program on schizophrenia and other psychiatric disorders and behavioral traits. The field has shown remarkable progress during the past decade, with abundant well-replicated findings of common and rare genetic variations associated with schizophrenia. The main thrust of CPG has been the design and implementation of large-scale, multi-site international studies, from systematic linkage scans to genome-wide association studies (GWAS) (see list of selected publications) and most recently, the follow-up functional studies to unravel the molecular mechanisms underlying genetic associations. The main approaches include GWAS, exome/genome sequencing, multi-omics, human induced pluripotent stem cells (hiPSC) models, and genome/epigenome editing.  Financial support derives from a variety of public and private sources, including NUH, The Brain and Behavior Research Foundation (formerly NARSAD, the National Alliance for Research on Schizophrenia and Depression), The Paul Michael Donovan Charitable Foundation, and Federal (NIH, National Institutes of Health) Research Grants.

PRINCIPAL Investigators:

Pablo V. Gejman, 224-364-7550
Vice President of Genomics Res and Dr. Louis W. Sauer Chair of Research                                                 
Director, Center for Psychiatric Genetics, NUH
Professor, Department of Psychiatry and Behavioral Neuroscience
The University of Chicago                                                      

Alan R. Sanders, 224-364-7560
Director, Behavior Genetics Unit
Associate Director, Center for Psychiatric Genetics, NUH
Clinical Associate Professor, Department of Psychiatry and Behavioral Neuroscience
The University of Chicago

Jubao Duan, 224-364-7564                                                                
Director, Unit of Functional Genomics in Psychiatry
Center for Psychiatric Genetics, NUH
Associate Professor, Department of Psychiatry and Behavioral Neuroscience
The University of Chicago

SELECTED Publications:

  1. Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model. Zhang S, Moy W, Zhang H, Leites C, McGowan H, Shi J, Sanders AR, Pang ZP, Gejman PV, Duan J. Stem Cell Res. 2018
  2. Genome-Wide Association Study of Male Sexual Orientation. Sanders AR, Beecham GW, Guo S, Dawood K, Rieger G, Badner JA, Gershon ES, Krishnappa RS, Kolundzija AB, Duan J; MGS Collaboration, Gejman PV, Bailey JM, Martin ER. Sci Rep. 2017
  3. Transcriptome sequencing study implicates immune-related genes differentially expressed in schizophrenia: new data and a meta-analysis. Sanders AR, Drigalenko EI, Duan J, Moy W, Freda J, Göring HHH, Gejman PV. Transl Psychiatry. 2017
  4. Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci. Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J. Cell Stem Cell. 2017
  5. Transcriptome outlier analysis implicates schizophrenia susceptibility genes and enriches putatively functional rare genetic variants. Duan J, Sanders AR, Moy W, Drigalenko EI, Brown EC, Freda J, Leites C, Göring HH; MGS, Gejman PV. Hum Mol Genet. 2015
  6. Genome-wide scan demonstrates significant linkage for male sexual orientation. Sanders AR, Martin ER, Beecham GW, Guo S, Dawood K, Rieger G, Badner JA, Gershon ES, Krishnappa RS, Kolundzija AB, Duan J, Gejman PV, Bailey JM. Psychol Med. 2015
  7. MicroRNA-9 and microRNA-326 regulate human dopamine D2 receptor expression and the microRNA-mediated expression regulation is altered by a genetic variant. Shi S, Leites C, He D, Schwartz D, Moy M, Shi J, Duan J.  J Biol Chem. 2014
  8. A rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorder. Duan J, Shi J, Fiorentino A, Leites C, Chen X, Moy W, Chen J, Alexandrov BS, Usheva A, He D, Freda J, O'Brien NL; Molecular Genetics of Schizophrenia collaboration; Genomic Psychiatric Cohort consortium, McQuillin A, Sanders AR, Gershon ES, DeLisi LE, Bishop AR, Gurling HM, Pato MT, Levinson DF, Kendler KS, Pato CN, Gejman PV. Am J Hum Genet. 2014
  9. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature. 2014
  10. Transcriptome study of differential expression in schizophrenia. Sanders AR, Göring HH (co-first author), Duan J, Drigalenko EI, Moy W, Freda J, He D, Shi J; MGS, Gejman PV. Hum Mol Genet. 2013
  11. Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, Lin DY, Duan J… 185  other authors …, O'Donovan MC, Daly MJ, Gejman PV. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011
  12. Genetics of Schizophrenia: New Findings and Challenges. Gejman PV, Sanders AR, Kendler KS. Annu Rev Genomics Hum Genet. 2011.
  13. Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Levinson DF, Duan J, Oh S, Wang K, Sanders AR, Shi J, Zhang N, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Kendler KS, Freedman R, Dudbridge F, Pe'er I, Hakonarson H, Bergen SE, Fanous AH, Holmans, PA, Gejman PV. Am J Psychiatry. 2011.
  14. The Internet-based MGS2 control sample: self report of mental illness. Sanders AR, Levinson DF, Duan J, Dennis JM, Li R, Kendler KS, Rice JP, Shi J, Mowry BJ, Amin F, Silverman JM, Buccola NG, Byerley WF, Black DW, Freedman R, Cloninger CR, Gejman PV. Am J Psychiatry. 2010.
  15. The role of genetics in the etiology of schizophrenia. Gejman PV, Sanders AR, Duan J. Psychiatr Clin North Am. 2010.
  16. Common variants on chromosome 6p22.1 are associated with schizophrenia. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, Dudbridge F, Holmans PA, Whittemore AS, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Crowe RR, Oksenberg JR, Mirel DB, Kendler KS, Freedman R, Gejman PV. Nature. 2009.
  17. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M, Gejman PV. Am J Psychiatry. 2008.
  18. New models of collaboration in genome-wide association studies: the Genetic Association Information Network. GAIN Collaborative Research Group, Manolio TA, Rodriguez LL, Brooks L, Abecasis G; Collaborative Association Study of Psoriasis, Ballinger D, Daly M, Donnelly P, Faraone SV; International Multi-Center ADHD Genetics Project, Frazer K, Gabriel S, Gejman PV; Molecular Genetics of Schizophrenia Collaboration, Guttmacher A, Harris EL, Insel T, Kelsoe JR; Bipolar Genome Study, Lander E, McCowin N, et al. Nat Genet. 2007.
  19. Genome wide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C, Buccola NG, Hale N, Weilbaecher AN, Nertney DA, Olincy A, Green S, Schaffer AW, Smith CJ, Hannah DE, Rice JP, Cox NJ, Martinez M, Mowry BJ, Amin F, Silverman JM, Black DW, Byerley WF, Crowe RR, Freedman R, Cloninger CR, Levinson DF, Gejman PV. Am J Hum Genet. 2006.
  20. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV. Hum Mol Genet. 2003.