Harriet de Wit, Ph.D

Professor, Department of Psychiatry and Behavioral Neuroscience
Biological Sciences Collegiate Division Committee on Neurobiology

5841 S. Maryland Ave., MC 3077, Rm L485
Chicago, Illinois 60637
Phone: 773-702-1537
Fax: 773-834-7698

 Website: Laboratory Website: http://psychiatry.uchicago.edu/hbpl/

Education & Training

  • PhD (Experimental Psychology), Concordia University Montreal, 1981
  • Registered Psychologist, State of Illinois (No. 072-003576)

Research Interests

  • Human psychopharmacology of substance abuse
  • Stress, impulsivity and cue reactivity
  • Drug- associated conditioning and learning


  • Course Director, Perspectives in Drug Abuse, Pha 329, 1992-
  • Research mentor, Illinois Mathematics and Science Academy, 1998-
  • Mentor, Summer Research Program, Pritzker School of Medicine, 2004-
  • Mentor, graduate students and post doctoral fellows
  • Training Faculty, Clinical Pharmacology Fellowship program, 1993-
  • Training Faculty, Integrative Neurobiology Training Grant (PI McGeehee), 2012-
  • Executive Committee, Psychiatric Genetics Training Grant (PI Palmer) 2013-
  • Course co-director and mentor, K-award training program, Institute of Translational Medicine, 2013-

Society Memberships

  • American College of Neuropsychopharmacology: Member 1996-; Fellow 2003-
  • American Psychological Association (Division 28): Fellow 1995-
  • Brain Research Institute, The University of Chicago, 1996-
  • Society for Neuroscience, 2002-
  • College on Problems of Drug Dependence: Fellow 2000-; Board of Directors 1997-2000
  • Research Society on Alcoholism: Board of Directors 1999-2003
  • Society for Research on Nicotine and Tobacco: Member 2004-
  • International Society of Addiction Journal Editors: Member 2006-

 Other Activities (non- University of Chicago)

  • Field Editor, Psychopharmacology, Alcohol and Substance Abuse in Humans; Human Cognitive Psychopharmacology, 1993 –
  • http://www.springer.com/biomed/neuroscience/journal/213
  • Interim Editor in Chief, Alcoholism: Clinical and Experimental Research, 2014
  • Scientific Advisory Board, Center for Drug Abuse Research Translation, University of Kentucky, 2004 –
  • Scientific Advisory Board, Alcohol Research Center, Oregon Health Sciences University, Portland Oregon, 2007 –
  • Consultant, Center for Drug Evaluation, Food and Drug Administration, 1991 -
  • Advisory Board, Current Drug Abuse Reviews, 2006 –
  • Member, Faculty of 1000, 2004-
  • Editorial Advisory Board The Open Addiction Journal, 2008 -
  • Member, International Society Addiction Journal Editors, 2006 – [http://www.parint.org/isajewebsite/index.htm]
  • Editorial Board, Encyclopedia of Psychopharmacology, Ed. Ian Stolerman, 2007 –
  • Editorial Board, Stress and Health, 2012 –
  • Scientific Advisory Board, Specialized Center of Research on Sex and Gender Factors Affecting Women’s Health, Medical College of South Carolina, 2012 –
  • Editorial Board, Current Addiction Reports (Ed. M. Potenza), 2013 –
  • Publications Committee, American College of Neuropsychopharmacology, 2013-
  • Editorial Board, PLOS ONE, 2013 –

 Other Activities (University of Chicago)

  • Scientific Advisory Committee, Clinical Research Center, 1989 -
  • Executive Committee, Clinical Pharmacology Fellowship Program, 1993 -
  • University of Chicago Cancer Research Center, 2004 -
  • Mentor, Illinois Mathematics and Science Academy, 1996 -
  • Member, Center for Cognitive and Social Neuroscience, 2005 -
  • Member, Faculty Advisory Committee of the Biostatistics Core Facility, 2007 –
  • Pritzker School of Medicine Summer Res Prog: Mentor, Cluster leader, Judge, 2004 –
  • Member, Faculty Advisory Committee, Biological Sciences Division 2012-2015 

  Selected Publications (2013-2014)

  • Wardle, M.C., A. Hart, A.A. Palmer, H. de Wit (2013)  Does COMT genotype influence the effects of d-amphetamine on executive functioning? Genes, Brain and Behavior 12, 13–20.  PMC3553317
  • Kirkpatrick, M.D., C.E. Johanson, H. de Wit (2013) Personality and the acute subjective effects of d-amphetamine in humans.  Journal of Psychopharmacology, 27. PMID: 23343596
  • Zorilla, E.P., M. Heilig, H. de Wit, Y. Shaham (2013)  Behavioral, biological and chemical perspectives on targeting CRF1 receptor antagonists to treat alcohol dependence.  Drug and Alcohol Dependence, 128, 175-86. PMC3596012
  • Dlugos, A., E. Childs, K. Stuhr, C.J. Hillard, H. de Wit (2012) Acute stress increases circulating N-acylethanolamines, including anandamide, in healthy humans. Neuropsychopharmacology, 37, 2416-27. PMC3442338
  • Morean, M.E., H.  de Wit, A.C King, M.Sofuoglu, S.Y. Rueger, & S.S. O'Malley (2013). The Drug Effects Questionnaire: Psychometric support across three drug types. Psychopharmacology, 227(1), 177-192. PMC3624068
  • Hart, A.B., H. de Wit, A.A. Palmer (2013).  Candidate gene studies of a promising intermediate phenotype: Failure to replicate. Neuropsychopharmacology. 38, 802-816.  PMC3671998
  • Ballard, M.E., D.A. Gallo, H. de Wit (2013).  Pre-encoding administration of amphetamine or THC selectively modulates emotional memory in humans. Psychopharmacology. 226, 515-529.  PMC3595317
  • Wardle, M.C., H. de Wit, I. Penton-Voak, G. Lewis, M.R. Munafo (2013).  Lack of association between COMT and working memory in a population-based cohort of healthy young adults. Neuropsychopharmacology. 38, 1253-1263.  PMC3656369
  • Mayo, L., D. Fraser, E. Childs, R. Momenan, D. Hommer, H. de Wit, M. Heilig (2013). Conditioned preference to a methamphetamine-associated contextual cue in humans. Neuropsychopharmacology. 38, 921-929. PMC3629404
  • Baggott, M.J., E. Childs, A.B. Hart, E. de Bruin, A.A. Palmer, J.E. Wilkinson, and H. de Wit (2013). Psychopharmacology of theobromine in healthy volunteers. Psychopharmacology228, 109-118. PMC3672386
  • Heinz, A.J., H. de Wit, T.C. Lilje, J.D. Kassel (2013) The combined effects of alcohol, caffeine and expectancies on subjective experience, impulsivity and risk-taking. Experimental and Clinical Psychopharmacology. 21, 222-234. PMID: 23750693 [PubMed - in process].
  • Kirkpatrick, M.G., H. de Wit (2013) In the company of others: Social factors alter acute alcohol response.  Psychopharmacology, 230, 215-26. PMC3800265
  • Weafer, J., H. de Wit (2013) Inattention, impulsive action, and subjective response to d-amphetamine.  Drug and Alcohol Dependence 133, 127-33. PMC3786022
  • Napier, T.C., A.A. Herrold, H. de Wit (2013) Using conditioned place preference in the development of relapse prevention medications.  Neuroscience and Biobehavioral Reviews, 37, 2081-6 PMC3815959
  • Childs, E., H. de Wit (2013) Contextual conditioning enhances the psychostimulant and incentive properties of d-amphetamine in humans.  Addiction Biology, 18, 985-92.  PMID: 22129527 [PubMed - in process]
  • Weafer, J., M.J. Baggott, H. de Wit (2013) Test-retest reliability of behavioral measures of impulsive choice, impulsive action, and impulsive inattention. Experimental and Clinical Psychopharmacology, 21, 475-81 PMID: 24099351 [PubMed - in process]
  • Ballard, E., D. Gallo, H. de Wit (2014) Amphetamine increases errors during episodic memory retrieval. Journal of Clinical Psychopharmacology, 34, 85-92 PMID: 24135845 [PubMed - as supplied by publisher]
  • Frye, C.G., M.C. Wardle, G.J. Norman, H. de Wit (2014) MDMA decreases the effects of simulated social rejection.  Pharmacology, Biochemistry and Behavior, 117, 1-6. PMC3910346
  • Weafer, J., D.Gallo, H. de Wit (2014) Amphetamine fails to alter cued recollection of emotional images: Study of encoding, retrieval, and state-dependency. Plos One. DOI: 10.1371/journal.pone.0090423
  • Weafer, J. and H. de Wit (in press). Sex differences in impulsive action and impulsive choice.  Addictive Behaviors. PMID:24286704 [PubMed - as supplied by publisher]
  • Kirkpatrick, M., R. Lee, M. Wardle, S. Jacob, H. de Wit (in press) Effects of MDMA and intranasal oxytocin on social and emotional processing. Neuropsychopharmacology. PMID: 24448644 [PubMed - as supplied by publisher]
  • Clark, D.B., H. de Wit, W. Iacono (in press). ADHD, Impulsivity and Substance Abuse: Methods, Results and Implications. Experimental and Clinical Psychopharmacology.
  • Wardle, M.C., M.G. Kirkpatrick, H. de Wit (in press) “Ecstasy” as a social drug: MDMA preferentially affects responses to emotional stimuli with social content.  Social Cognitive and Affective Neuroscience. doi: 10.1093/scan/nsu035
  • Kirkpatrick, M.G., M.J. Baggott, J.E. Mendelson, G.P. Galloway, M.E Liechti, C.M Hysek, H. de Wit (in press). MDMA effects are consistent across controlled laboratory settings. Psychopharmacology.
  • Hart, A.B., E.R. Gamazon, B. E. Engelhardt, P. Sklar, C. Hultman, Pa. F. Sullivan, B. Neale, S.V. Faraone, Psychiatric Genomics Consortium: ADHD Subgroup, H. de Wit, N. J. Cox, A.A. Palmer (in press).  Genetic variation associated with the euphorigenic effects of d-amphetamine is also associated with diminished risk for schizophrenia and ADHD. Proceedings of the National Academy of Sciences.
  • Bedi, G, G. Cecchi, D.F. Slezak, F. Carrillo, M. Sigma, H. de Wit (in press).  A window into the intoxicated mind:  Speech as an index of psychoactive drug effects.  Neuropsychopharmacology.
  • Wardle, M.C., H. de Wit (in press).  MDMA alters emotional processing and facilitates social interaction.  Psychopharmacology.
  • Kirkpatrick, M.G., S. M. Francis, R. Lee, H. de Wit, S. Jacob (in press).  Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology.
  • Childs, E., H. de Wit (in press). Regular exercise is associated with emotional resilience to acute stress in healthy adults. Frontiers in Physiology.
  • Wardle, M., D. Fitzgerald, M. Angstadt, C. Rabinak, H. de Wit, K.L. Phan (in press). Effects of oxycodone on brain responses to emotional images.  Psychopharmacology.