Royce Lee, M.D.

Associate Professor

5841 S. Maryland Ave., MC 3077
Chicago, Illinois 60637


Education & Training

  • College: Northwestern University, 1989-1992.
  • Medical School: Northwestern University Feinberg School of Medicine, 1992-1996.
  • Residency: General Adult Psychiatry, Rush Medical School, 1996-1999, Chief Residency, 2000
  • Post-doctor Research Fellowship: Clinical electrophysiology, The University of Chicago, 2007 

Clinical Interests

  • Personality disorder
  • Major depressive disorder
  • Posttraumatic stress disorder

Research Interests

  • Stress neuropeptides
  • EEG
  • Childhood Trauma


  • Neuroscience for Psychiatrists

Society Memberships

  • American Psychiatric Association

Ongoing Research

  • An Exploratory Phase II Study to Determine the Safety, Tolerability and Activity of a Novel Vasopressin 1a Receptor Antagonist (SRX246) in Adults with DSM-5 Intermittent Explosive Disorder (IED)
  • Deep Brain Recording During Performance Monitoring in Obsessive-Compulsive Disorder.

Selected Publications

  • Kirkpatrick MG, Francis SM, Lee R, de Wit H, Jacob S. Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology. 2014;46: 23-31.
  • Lee RJ, Coccaro EF, Cremers H, McCarron R, Lu SF, Brownstein M, Simon NG: A novel V1a receptor antagonist blocks vasopressin-induced changes in the CNS response to emotional stimuli: an fMRI study. Frontiers in Integrative Neuroscience 2013; 7: 100.
  • Coccaro EF, Lee R, Coussons-Read M: Elevated plasma inflammatory markers in individuals with intermittent explosive disorder and correlation with aggression in humans. JAMA Psychiatry 2013; 1: 158-65.
  • Lee RJ, Hempel J, Tenharmsel A, Liu T, Mathe AA, Klock A: The neuroendocrinology of childhood trauma in personality disorder. Psychoneuroendocrinology 2012; 37: 78 – 86
  • Lee RJ, Gill A, Chen B, McCloskey M, Coccaro EF: Modulation of central serotonin affects emotional information processing in impulsive aggressive personality disorder. Journal of Clinical Psychopharmacology 2012; 32: 329 – 35
  • Lee RJ, Coccaro EF: Childhood trauma and personality disorder: Toward a biological model. Current Psychiatry Reports 2006; 8: 43 – 52
  • Lee R, Petty F, Coccaro EF: Cerebrospinal fluid GABA concentration: Relationship with impulsivity and history of suicidal behavior, but not aggression, in human subjects. J Psychiatr Res. 2008 May 17
  • Lee R, Gollan J, Kasckow J, Geracioti T, Coccaro EF: CSF corticotropin-releasing factor in personality disorder: relationship with perceived parental care and CSF 5-HIAA. Neuropsychopharmacology 2006; 31: 2289 – 95