Research

Jon Grant, MD, JD, MPH., Director of the Research Mission

Dr. Grant is a Professor of Psychiatry & Behavioral Neuroscience at the University of Chicago where he directs a clinic and research lab on addictive, compulsive and impulsive disorders. Dr. Grant is the author of over 350 peer-reviewed scientific articles, 15 books, and is the Editor in Chief of the Journal of Gambling Studies.
 

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Faculty Research Topics

The Clinical Addictions Research Laboratory (CARL) examines the consequences, predisposing factors, and treatment for addictive disorders.  The goals of the laboratory are twofold: a) to improve our understanding about the mechanisms of risk for substance use disorders, and b) to examine pharmacological and psychological interventions for the treatment of substance use disorders.  The laboratory is currently conducting the Chicago Social Drinking Project (CSDP), the Chicago Stop Smoking Research Project (C-STOP), the Social Smoking Moods and Behaviors Study (SSMB) and the Social Smoker Brain Imaging Project (SSBI).  For more information on these studies, please visit our web site, http://addiction.uchicago.edu.  In the past several years, the researchers at CARL have also conducted pilot stop-smoking studies for community-based treatment in the south side Chicago neighborhoods and on the University of Chicago campus.

Director: Andrea King, Ph.D.

Andrea C. King

Professor of Grossman Institute for Neuroscience
Professor of Psychiatry and Behavioral Neuroscience

 

The CNPRU is a clinical research group here in the Department of Psychiatry headed by Emil F. Coccaro, M.D. We offer Clinical Trials for people who are experiencing difficulty in their lives in areas such as problems with anger, depression, and anxiety. We also run a study of Pennsylvania Twins. New studies and new areas of interest are always opening up, so please visit our home page to learn more!

We are currently supported to study the EEG and behavioral effects of neuropeptides administered to the olfactory epithelium in human volunteers. We have ongoing psychopharmacological experiments with insulin, corticotropin-releasing factor, oxytocin, and vasopressin. In parallel with this work, we are engaged in a rigorous examination of the neurophysiological correlates of neuropeptide effects on the brain, as well as of mental processing of emotion-relevant stimuli, such as emotional faces. This work includes multimodal imaging (scalp and intracranial EEG and fMRI). Our goal is to develop novel therapeutic and prognostic tools for the treatment of neurotic disorders. For more information, contact Royce Lee, MD.

Royce Lee

Associate Professor of Psychiatry and Behavioral Neuroscience

 

Bipolar disorder

Borderline Personality Disorder  video

Couples Study

Depression

Eating Disorder studies                                                                      

Intermittent Explosive Disorder / Aggression

Loneliness

Smoking

Obsessive-Compulsive Disorder (OCD)

Schizophrenia or Schizoaffective Disorder

Skin Picking

Trichotillomania (hair pulling)

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Some studies of psychiatric disorders require comparison with individuals who do not have disorders.  Also, some studies in our department seek to understand normal cognitive, developmental, or emotional processes in healthy individuals. 

  • Cacioppo, Stephanie, Ph.D.                                                              
    Neuroimaging of Salutary Connections in Health Disease
  • Coccaro, Emil, M.D.
    Behavioral genetics and neuroscience of aggression
  • Duan, Jubao, Ph.D.                                                                     
    Molecular basis of schizophrenia and other neuropsychiatric disorders
  • De Wit, Harriet, Ph.D.
    Individual differences in responding to drugs of abuse in humans
  • Gejman, Pablo, M.D.                                                                           
    Clinical and molecular aspects of psychiatric genetics
  • Gershon, Elliot, M.D.
    Genetics of bipolar manic-depressive illness
  • Grant, Jon, J.D., M.D., M.P.H.                                                        
    Treatments for compulsive and impulsive behaviors
  • Jacobson, Kristen, Ph.D                                                                
    Behavioral genetics of conduct problems, aggression, and substance abuse
  • Keedy, Sarah, Ph.D.                                                                      
    Neurocognitive abnormalities and treatment changes in psychotic disorders
  • Keenan, Kathryn, Ph.D.
    Individual differences in risk for development of psychopathology
  • King, Andrea, Ph.D.
    Mechanisms underlying vulnerability for substance use disorders
  • Lee, Royce, M.D. 
    Role of neuropeptides in emotion and stress-related psychiatric disorders              
  •  Sanders, Alan, M.D.                                                                   
    Genetics factors in major psychiatric disorders and behavioral traits.                                               
  • Wildes, Jennifer, Ph.D.                                                              
    Psychopathology and treatment of eating disorders

Research Resources