People

Harriet De Wit, PhD

  • Professor of Psychiatry and Behavioral Neuroscience
    Professor of Grossman Institute for Neuroscience
  • Research and Scholarly Interests: Addiction, Substance, Conditioning (Psychology), Human, Imaging, Magnetic Resonance, Inhibition (Psychology), Mood, Psychopharmacology, Reward
  • Websites: dewitlab, Research Network Profile
  • Contact: hdew@uchicago.edu

The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.

Concordia University
Montreal Canada
PhD - Experimental Psychology
1981

University of Calgary
Calgary Canada
BA - Psychology
1969

Association between impulsivity traits and body mass index at the observational and genetic epidemiology level.
Meyre D, Mohamed S, Gray JC, Weafer J, MacKillop J, de Wit H. Association between impulsivity traits and body mass index at the observational and genetic epidemiology level. Sci Rep. 2019 Nov 26; 9(1):17583.
PMID: 31772290

Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.
Langenecker SA, Kling LR, Crane NA, Gorka SM, Nusslock R, Damme KSF, Weafer J, de Wit H, Luan Phan K. Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration. Drug Alcohol Depend. 2019 Nov 07; 107725.
PMID: 31757518

?9-Tetrahydrocannabinol During Encoding Impairs Perceptual Details yet Spares Context Effects on Episodic Memory.
Doss MK, Weafer J, Gallo DA, de Wit H. ?9-Tetrahydrocannabinol During Encoding Impairs Perceptual Details yet Spares Context Effects on Episodic Memory. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Aug 30.
PMID: 31668830

Developing a phone-based measure of impairment after acute oral ?9-tetrahydrocannabinol.
Pabon E, de Wit H. Developing a phone-based measure of impairment after acute oral ?9-tetrahydrocannabinol. J Psychopharmacol. 2019 Sep; 33(9):1160-1169.
PMID: 31407943

MDMA enhances pleasantness of affective touch.
de Wit H, Bershad AK. MDMA enhances pleasantness of affective touch. Neuropsychopharmacology. 2020 Jan; 45(1):217-239.
PMID: 31391575

Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability.
Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability. Nat Neurosci. 2019 Jul; 22(7):1196.
PMID: 31168101

Subjective responses to amphetamine in young adults with previous mood elevation experiences.
Schepers ST, Arndt DL, Rogers RD, Hedeker D, de Wit H. Subjective responses to amphetamine in young adults with previous mood elevation experiences. Psychopharmacology (Berl). 2019 Nov; 236(11):3363-3370.
PMID: 31209507

Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers.
Bershad AK, Schepers ST, Bremmer MP, Lee R, de Wit H. Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers. Biol Psychiatry. 2019 Nov 15; 86(10):792-800.
PMID: 31331617

Oxytocin Reduces Cigarette Consumption in Daily Smokers.
Van Hedger K, Kushner MJ, Lee R, de Wit H. Oxytocin Reduces Cigarette Consumption in Daily Smokers. Nicotine Tob Res. 2019 May 21; 21(6):799-804.
PMID: 29701814

Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults.
Weafer J, Van Hedger K, Keedy SK, Nwaokolo N, de Wit H. Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults. Addict Biol. 2019 May 16; e12775.
PMID: 31099141

View All Publications

Distinguished Achievement Award
European Behavioural Pharmacology Society
2019

Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016

Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009

Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999