The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.
University of Calgary
Calgary Canada
BA - Psychology
1969
Concordia University
Montreal Canada
PhD - Experimental Psychology
02/1981
Reinforcing effects of extended inhalation of nitrous oxide in humans.
Dohrn CS, Lichtor JL, Coalson DW, Uitvlugt A, de Wit H, Zacny JP. Reinforcing effects of extended inhalation of nitrous oxide in humans. Drug Alcohol Depend. 1993 Feb; 31(3):265-80.
PMID: 8462415
Subjective and psychomotor effects of nitrous oxide in healthy volunteers.
Dohrn CS, Lichtor JL, Finn RS, Uitvlugt A, Coalson DW, Rupani G, de Wit H, Zacny JP. Subjective and psychomotor effects of nitrous oxide in healthy volunteers. Behav Pharmacol. 1992 Feb; 3(1):19-30.
PMID: 11224098
Subjective responses to amphetamine in young adults with previous mood elevation experiences.
Schepers ST, Arndt DL, Rogers RD, Hedeker D, de Wit H. Subjective responses to amphetamine in young adults with previous mood elevation experiences. Psychopharmacology (Berl). 2019 Jun 17.
PMID: 31209507
Sweet taste liking is associated with subjective response to amphetamine in women but not men.
Weafer J, Lyon N, Hedeker D, de Wit H. Sweet taste liking is associated with subjective response to amphetamine in women but not men. Psychopharmacology (Berl). 2017 Nov; 234(21):3185-3194.
PMID: 28762072
Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity.
Weafer J, Gorka SM, Hedeker D, Dzemidzic M, Kareken DA, Phan KL, de Wit H. Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity. Neuropsychopharmacology. 2017 Aug; 42(9):1905-1913.
PMID: 28303900
Effects of d-amphetamine in grouped versus isolated humans.
de Wit H, Clark M, Brauer LH. Effects of d-amphetamine in grouped versus isolated humans. Pharmacol Biochem Behav. 1997 May-Jun; 57(1-2):333-40.
PMID: 9164591
Evaluation of phentermine and fenfluramine, alone and in combination, in normal, healthy volunteers.
Brauer LH, Johanson CE, Schuster CR, Rothman RB, de Wit H. Evaluation of phentermine and fenfluramine, alone and in combination, in normal, healthy volunteers. Neuropsychopharmacology. 1996 Apr; 14(4):233-41.
PMID: 8924191
Acute tolerance to subjective but not cardiovascular effects of d-amphetamine in normal, healthy men.
Brauer LH, Ambre J, De Wit H. Acute tolerance to subjective but not cardiovascular effects of d-amphetamine in normal, healthy men. J Clin Psychopharmacol. 1996 Feb; 16(1):72-6.
PMID: 8834422
Subjective responses to d-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers.
Brauer LH, de Wit H. Subjective responses to d-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers. Biol Psychiatry. 1996 Jan 01; 39(1):26-32.
PMID: 8719123
Acute subjective responses to paroxetine in normal volunteers.
Brauer LH, Rukstalis MR, de Wit H. Acute subjective responses to paroxetine in normal volunteers. Drug Alcohol Depend. 1995 Oct; 39(3):223-30.
PMID: 8556971
Distinguished Achievement Award
European Behavioural Pharmacology Society
2019
Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016
Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009
Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999