People

Harriet De Wit, PhD

  • Professor of Psychiatry and Behavioral Neuroscience
    Committee on Clinical Pharmacology and Pharmacogenomics
  • Research and Scholarly Interests: Addiction, Substance, Conditioning (Psychology), Human, Imaging, Magnetic Resonance, Inhibition (Psychology), Mood, Psychopharmacology, Reward
  • Websites: dewitlab, Research Network Profile
  • Contact: hdew@yoda.bsd.uchicago.edu

The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.

Concordia University
Montreal Canada
PhD - Experimental Psychology
1981

University of Calgary
Calgary Canada
BA - Psychology
1969

Psychedelics: Old trips, new destinations in psychopharmacology research.
de Wit H, D'Souza DC. Psychedelics: Old trips, new destinations in psychopharmacology research. Psychopharmacology (Berl). 2022 Jun; 239(6):1643-1645.
PMID: 35460341

Correction to: Psychedelics: Old trips, new destinations in psychopharmacology research.
de Wit H, D'Souza DC. Correction to: Psychedelics: Old trips, new destinations in psychopharmacology research. Psychopharmacology (Berl). 2022 Jun; 239(6):1647.
PMID: 35543715

?9-THC reduces reward-related brain activity in healthy adults.
Murray CH, Glazer JE, Lee R, Nusslock R, de Wit H. ?9-THC reduces reward-related brain activity in healthy adults. Psychopharmacology (Berl). 2022 Sep; 239(9):2829-2840.
PMID: 35612654

Effects of Oral Delta-9-Tetrahydrocannabinol in Women During the Follicular Phase of the Menstrual Cycle.
Pabon E, de Wit H. Effects of Oral Delta-9-Tetrahydrocannabinol in Women During the Follicular Phase of the Menstrual Cycle. Cannabis Cannabinoid Res. 2022 May 20.
PMID: 35593915

Effect of Combination Treatment With Varenicline and Nicotine Patch on Smoking Cessation Among Smokers Who Drink Heavily: A Randomized Clinical Trial.
King A, Vena A, de Wit H, Grant JE, Cao D. Effect of Combination Treatment With Varenicline and Nicotine Patch on Smoking Cessation Among Smokers Who Drink Heavily: A Randomized Clinical Trial. JAMA Netw Open. 2022 Mar 01; 5(3):e220951.
PMID: 35244704

Adolescents are more sensitive than adults to acute behavioral and cognitive effects of THC.
Murray CH, Huang Z, Lee R, de Wit H. Adolescents are more sensitive than adults to acute behavioral and cognitive effects of THC. Neuropsychopharmacology. 2022 06; 47(7):1331-1338.
PMID: 35110688

Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women.
Wardle MC, Pabon E, Webber HE, de Wit H. Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women. Psychopharmacology (Berl). 2022 May; 239(5):1487-1497.
PMID: 35102424

Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study.
de Wit H, Molla HM, Bershad A, Bremmer M, Lee R. Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study. Addict Biol. 2022 03; 27(2):e13143.
PMID: 35106880

Effects of Methamphetamine on Within- and Between-Network Connectivity in Healthy Adults.
Malina M, Keedy S, Weafer J, Van Hedger K, de Wit H. Effects of Methamphetamine on Within- and Between-Network Connectivity in Healthy Adults. Cereb Cortex Commun. 2021; 2(4):tgab063.
PMID: 34859242

Does ±3,4-methylenedioxymethamphetamine (ecstasy) induce subjective feelings of social connection in humans? A multilevel meta-analysis.
Regan A, Margolis S, de Wit H, Lyubomirsky S. Does ±3,4-methylenedioxymethamphetamine (ecstasy) induce subjective feelings of social connection in humans? A multilevel meta-analysis. PLoS One. 2021; 16(10):e0258849.
PMID: 34695117

View All Publications

Lifetime Achievement Award
Research Society on Alcoholism
2020

John F. Lemieux Medal for Distinguished Alumni
Concordia University, Montreal
2020

Distinguished Achievement Award
European Behavioural Pharmacology Society
2019

Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016

Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009

Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999