People

Harriet De Wit, PhD

The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.

Concordia University
Montreal Canada
PhD - Experimental Psychology
1981

University of Calgary
Calgary Canada
BA - Psychology
1969

Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine.
Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine. Neuropsychopharmacology. 2024 Jan 29.
PMID: 38287172

MDMA enhances positive affective responses to social feedback.
MDMA enhances positive affective responses to social feedback. J Psychopharmacol. 2024 Jan 27; 2698811231224153.
PMID: 38279662

Microdosing psychedelics: Current evidence from controlled studies.
Microdosing psychedelics: Current evidence from controlled studies. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jan 25.
PMID: 38280630

Impulsivity and Psychiatric Diagnoses as Mediators of Suicidal Ideation and Suicide Attempts Among Veterans With Traumatic Brain Injury.
Impulsivity and Psychiatric Diagnoses as Mediators of Suicidal Ideation and Suicide Attempts Among Veterans With Traumatic Brain Injury. J Neuropsychiatry Clin Neurosci. 2024 Jan 09; appineuropsych20230044.
PMID: 38192217

Lack of effect of methamphetamine on reward-related brain activity in healthy adults.
Lack of effect of methamphetamine on reward-related brain activity in healthy adults. Psychopharmacology (Berl). 2024 Jan; 241(1):181-193.
PMID: 38141075

Unique effects of sedatives, dissociatives, psychedelics, stimulants, and cannabinoids on episodic memory: A review and reanalysis of acute drug effects on recollection, familiarity, and metamemory.
Unique effects of sedatives, dissociatives, psychedelics, stimulants, and cannabinoids on episodic memory: A review and reanalysis of acute drug effects on recollection, familiarity, and metamemory. Psychol Rev. 2023 Dec 14.
PMID: 38095937

Greater subjective effects of a low dose of LSD in participants with depressed mood.
Greater subjective effects of a low dose of LSD in participants with depressed mood. Neuropsychopharmacology. 2023 Dec 02.
PMID: 38042914

Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations.
Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations. Sci Rep. 2023 09 22; 13(1):15846.
PMID: 37740024

Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia.
Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia. Schizophr Bull. 2023 09 07; 49(5):1161-1173.
PMID: 37358825

Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men.
Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men. Cereb Cortex. 2023 08 08; 33(16):9478-9488.
PMID: 37339883

View All Publications

Lifetime Achievement Award
Research Society on Alcoholism
2020

John F. Lemieux Medal for Distinguished Alumni
Concordia University, Montreal
2020

Distinguished Achievement Award
European Behavioural Pharmacology Society
2019

Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016

Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009

Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999