The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.
Concordia University
Montreal Canada
PhD - Experimental Psychology
1981
University of Calgary
Calgary Canada
BA - Psychology
1969
Acute effects of oral delta-9-tetrahydrocannabinol (THC) on autonomic cardiac activity and their relation to subjective and anxiogenic effects.
Pabon E, Rockwood F, Norman GJ, de Wit H. Acute effects of oral delta-9-tetrahydrocannabinol (THC) on autonomic cardiac activity and their relation to subjective and anxiogenic effects. Psychophysiology. 2021 Oct 19; e13955.
PMID: 34665890
Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults.
Murray CH, Tare I, Perry CM, Malina M, Lee R, de Wit H. Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults. Psychopharmacology (Berl). 2021 Oct 06.
PMID: 34613430
The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence.
Di Ciano P, de Wit H, Mansouri E, Houle S, Boileau I, Le Foll B. The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence. Sci Rep. 2021 06 03; 11(1):11667.
PMID: 34083612
Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.
Weafer J, Gorka SM, Dzemidzic M, Kareken DA, Phan KL, de Wit H. Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol. Neuropsychopharmacology. 2021 07; 46(8):1442-1450.
PMID: 33947965
Challenges in translational research: MDMA in the laboratory versus therapeutic settings.
de Wit H, Bershad AK, Grob C. Challenges in translational research: MDMA in the laboratory versus therapeutic settings. J Psychopharmacol. 2021 May 04; 2698811211015221.
PMID: 33944625
Can MDMA Change Sociopolitical Values? Insights From a Research Participant.
de Wit H, Bershad AK, Hutchison W, Bremmer M. Can MDMA Change Sociopolitical Values? Insights From a Research Participant. Biol Psychiatry. 2021 06 01; 89(11):e61-e62.
PMID: 33814127
Effects of Acute Drug Administration on Emotion: A Review of Pharmacological MRI Studies.
Van Hedger K, Mayo LM, Bershad AK, Madray R, de Wit H. Effects of Acute Drug Administration on Emotion: A Review of Pharmacological MRI Studies. Curr Addict Rep. 2021 Jun; 8(2):181-193.
PMID: 34631363
Subjective responses predict d-amphetamine choice in healthy volunteers.
Murray CH, Li J, Weafer J, de Wit H. Subjective responses predict d-amphetamine choice in healthy volunteers. Pharmacol Biochem Behav. 2021 05; 204:173158.
PMID: 33675838
Acute effects of alcohol on resting-state functional connectivity in healthy young men.
Han J, Keedy S, Murray CH, Foxley S, de Wit H. Acute effects of alcohol on resting-state functional connectivity in healthy young men. Addict Behav. 2021 04; 115:106786.
PMID: 33421747
Neural activation during anticipation of monetary gain or loss does not associate with positive subjective response to alcohol in binge drinkers.
Pabon E, Crane NA, Radoman M, Weafer J, Langenecker SA, Phan KL, de Wit H. Neural activation during anticipation of monetary gain or loss does not associate with positive subjective response to alcohol in binge drinkers. Drug Alcohol Depend. 2021 01 01; 218:108432.
PMID: 33250380
Lifetime Achievement Award
Research Society on Alcoholism
2020
John F. Lemieux Medal for Distinguished Alumni
Concordia University, Montreal
2020
Distinguished Achievement Award
European Behavioural Pharmacology Society
2019
Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016
Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009
Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999