The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.
Concordia University
Montreal Canada
PhD - Experimental Psychology
1981
University of Calgary
Calgary Canada
BA - Psychology
1969
Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia.
Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia. Schizophr Bull. 2023 09 07; 49(5):1161-1173.
PMID: 37358825
Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men.
Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men. Cereb Cortex. 2023 08 08; 33(16):9478-9488.
PMID: 37339883
The acute effects of psychoactive drugs on emotional episodic memory encoding, consolidation, and retrieval: A comprehensive review.
The acute effects of psychoactive drugs on emotional episodic memory encoding, consolidation, and retrieval: A comprehensive review. Neurosci Biobehav Rev. 2023 07; 150:105188.
PMID: 37085021
Impaired inhibition after delta-9-tetrahydrocannabinol in women not related to circulating estradiol levels.
Impaired inhibition after delta-9-tetrahydrocannabinol in women not related to circulating estradiol levels. Pharmacol Biochem Behav. 2023 04; 225:173547.
PMID: 37004978
Progress and Puzzles in Psychedelic Therapy.
Progress and Puzzles in Psychedelic Therapy. Biol Psychiatry. 2023 02 01; 93(3):210.
PMID: 36567083
Place conditioning in humans: opportunities for translational research.
Place conditioning in humans: opportunities for translational research. Psychopharmacology (Berl). 2023 Jan 19.
PMID: 36656336
Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity.
Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity. Neuropsychopharmacology. 2022 Oct 25.
PMID: 36284231
Pharmacological investigations of effort-based decision-making in humans: Naltrexone and nicotine.
Pharmacological investigations of effort-based decision-making in humans: Naltrexone and nicotine. PLoS One. 2022; 17(10):e0275027.
PMID: 36197897
Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning-after effects.
Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning-after effects. Alcohol Clin Exp Res. 2022 10; 46(10):1875-1887.
PMID: 35953878
Correction to: Psychedelics: Old trips, new destinations in psychopharmacology research.
Correction to: Psychedelics: Old trips, new destinations in psychopharmacology research. Psychopharmacology (Berl). 2022 Jun; 239(6):1647.
PMID: 35543715
Lifetime Achievement Award
Research Society on Alcoholism
2020
John F. Lemieux Medal for Distinguished Alumni
Concordia University, Montreal
2020
Distinguished Achievement Award
European Behavioural Pharmacology Society
2019
Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016
Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009
Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999