People

Harriet De Wit, PhD

  • Professor of Psychiatry and Behavioral Neuroscience
    Committee on Clinical Pharmacology and Pharmacogenomics
  • Research and Scholarly Interests: Addiction, Substance, Conditioning (Psychology), Human, Imaging, Magnetic Resonance, Inhibition (Psychology), Mood, Psychopharmacology, Reward
  • Websites: dewitlab, Research Network Profile
  • Contact: hdew@yoda.bsd.uchicago.edu

The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.

Concordia University
Montreal Canada
PhD - Experimental Psychology
1981

University of Calgary
Calgary Canada
BA - Psychology
1969

Effect of Combination Treatment With Varenicline and Nicotine Patch on Smoking Cessation Among Smokers Who Drink Heavily: A Randomized Clinical Trial.
King A, Vena A, de Wit H, Grant JE, Cao D. Effect of Combination Treatment With Varenicline and Nicotine Patch on Smoking Cessation Among Smokers Who Drink Heavily: A Randomized Clinical Trial. JAMA Netw Open. 2022 Mar 01; 5(3):e220951.
PMID: 35244704

Adolescents are more sensitive than adults to acute behavioral and cognitive effects of THC.
Murray CH, Huang Z, Lee R, de Wit H. Adolescents are more sensitive than adults to acute behavioral and cognitive effects of THC. Neuropsychopharmacology. 2022 Feb 02.
PMID: 35110688

Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women.
Wardle MC, Pabon E, Webber HE, de Wit H. Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women. Psychopharmacology (Berl). 2022 Feb 01.
PMID: 35102424

Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study.
de Wit H, Molla HM, Bershad A, Bremmer M, Lee R. Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study. Addict Biol. 2022 03; 27(2):e13143.
PMID: 35106880

Effects of Methamphetamine on Within- and Between-Network Connectivity in Healthy Adults.
Malina M, Keedy S, Weafer J, Van Hedger K, de Wit H. Effects of Methamphetamine on Within- and Between-Network Connectivity in Healthy Adults. Cereb Cortex Commun. 2021; 2(4):tgab063.
PMID: 34859242

Does ±3,4-methylenedioxymethamphetamine (ecstasy) induce subjective feelings of social connection in humans? A multilevel meta-analysis.
Regan A, Margolis S, de Wit H, Lyubomirsky S. Does ±3,4-methylenedioxymethamphetamine (ecstasy) induce subjective feelings of social connection in humans? A multilevel meta-analysis. PLoS One. 2021; 16(10):e0258849.
PMID: 34695117

Acute effects of oral delta-9-tetrahydrocannabinol (THC) on autonomic cardiac activity and their relation to subjective and anxiogenic effects.
Pabon E, Rockwood F, Norman GJ, de Wit H. Acute effects of oral delta-9-tetrahydrocannabinol (THC) on autonomic cardiac activity and their relation to subjective and anxiogenic effects. Psychophysiology. 2022 02; 59(2):e13955.
PMID: 34665890

Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults.
Murray CH, Tare I, Perry CM, Malina M, Lee R, de Wit H. Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults. Psychopharmacology (Berl). 2021 Oct 06.
PMID: 34613430

The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence.
Di Ciano P, de Wit H, Mansouri E, Houle S, Boileau I, Le Foll B. The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence. Sci Rep. 2021 06 03; 11(1):11667.
PMID: 34083612

Challenges in translational research: MDMA in the laboratory versus therapeutic settings.
de Wit H, Bershad AK, Grob C. Challenges in translational research: MDMA in the laboratory versus therapeutic settings. J Psychopharmacol. 2022 Mar; 36(3):252-257.
PMID: 33944625

View All Publications

Lifetime Achievement Award
Research Society on Alcoholism
2020

John F. Lemieux Medal for Distinguished Alumni
Concordia University, Montreal
2020

Distinguished Achievement Award
European Behavioural Pharmacology Society
2019

Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016

Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009

Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999